“Not just herniated disc” back pain: Outcome of oxygen-ozone treatment in selected applications.

Authors

  • Matteo Bonetti Dept Neuroradiology Istituto Clinico Città Di Brescia
  • Alessio Zambello Dept of Anesthesiology – “Fondazione Borghi” Hospital Brebbia (Varese)
  • Marco Leonardi Dept of Neuroradiology, IRCCS Institute of Neurological Sciences of Bologna, Bologna DIMES Dept University of Bologna, Bologna
  • Ciro Princiotta Dept of Neuroradiology, IRCCS Institute of Neurological Sciences of Bologna, Bologna

DOI:

https://doi.org/10.7203/jo3t.4.5.2020.10811

Keywords:

Oxygen-ozone, Ozone therapy, facet synovitis, Baastrup syndrome, Spondylolysis, Spondylolisthesis, Facet degeneration

Abstract

Low back pain and sciatica are highly debilitating conditions affecting all socioeconomic groups at an increasingly early age. They are caused by different often concomitant spinal disorders: disc or facet joint disease, spondylolisthesis (with or without listhesis), vertebral body and interapophyseal arthrosis, spinal stenosis, radicular and synovial cysts and, more rarely, infections and primary or metastatic cancer.

Treatment of low back pain and/or sciatica requires an accurate diagnosis based on thorough history-taking and physical examination followed by appropriate imaging tests, namely computed tomography and/or magnetic resonance scans in addition to standard X-rays of the spine.

In recent years, several reports have demonstrated the utility of oxygen-ozone therapy in reducing the size of herniated discs. The present study reports on the outcome of oxygen-ozone treatment in 416 patients with non-discogenic low back pain caused by degenerative disease of the posterior vertebral compartment (facet synovitis, Baastrup syndrome, spondylolysis and spondylolisthesis, facet degeneration). 

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References

Andreula CF, Simonetti L, De-Santis F, Agati R, Ricci R, Leonardi M. Minimally Invasive Oxygen-Ozone Therapy for Lumbar Disk Herniation. AJNR. 2003;24:996-1000.

Barbara C, Simonetti L, Giatti S, Leonardi M. Trattamento percutaneo dell'ernia discale con iniezione intradiscale di miscela di ozono. Risultati preliminari. Riv Neuroradiol. 1999;12(4 suppl):39.

Bonetti M, Fontana A, Cotticelli B, Dalla-Volta G, Guindani M, Leonardi M. Intraforaminal O2-O3 versus periradicular steroidal infiltrations in lower back pain: randomized controlled study. AJNR. 2005;26:996-1000.

Bonetti M, Cotticelli B, Raimondi D, Valdenassi L, Richelmi P, Bertè FA. (2000) Ossigeno-ozono terapia vs infiltrazioni epidurali cortisoniche. Riv Neuroradiol. 2000;13:203-206.

Dall’Olio M, Princiotta C, Cirillo L, Budai C, de Santis F, Bartolini S, Serchi E, Leonardi M. Oxygen-Ozone Therapy for Herniated Lumbar Disc in Patients with Subacute Partial Motor Weakness Due to Nerve Root Compression. Interv Neuroradiol. 2014;20:547-554.

De-Santis F, Leonardi M, Simonetti L, Dall’Olio M, Princiotta C, Menetti F. Ossigeno-Ozonoterapia: la tecnica intradiscale. Int J Ozone Therap 2009;8:138-146.

Gallucci M, Limbucci N, Zugaro L, Barile A, Stavroulis E, Ricci A, Galzio R, et al. Sciatica: treatment with intradiscal and intraforaminal injections of steroid and oxygen-ozone versus steroid only. Radiology. 2007;242(3):907-913. doi:10.1148/radiol.2423051934

Gualandi G., Bonetti M. Ossigeno-ozonoterapia nel trattamento della patologia dolorosa del rachide lombare: esperienza preliminare. Acta Toxic Therap. 1996;17(2-3):261-264.

Iliakis E. Ozone treatment in low back pain. Orthopaedics. 1995;1:29-33.

Iliakis E., Valadakis V., Vynios D.H., Tsiganos C.P., Agapitos E. Rationalization of the activity of medical ozone on intervertebral disc and histological and biochemical study. Riv Neuroradiol. 2001;14(1 suppl):25-30.

Lehnert T, Naguib NN, Wutzler S, Nour-Eldin NE, Bauer RW, Kerl JM, Vogl TJ. Analysis of disk volume before and after CT-guided intradiscal and periganglionic ozone-oxygen injection for the treatment of lumbar disk herniation. J Vasc Interv Radiol. 2012;23(11):1430-1436.

Leonardi M, Albini Riccioli L, Battaglia S, de Santis F, Cenni P, Raffi L, Simonetti L. Oxygen-ozone chemonucleolysis for herniated disc with sciatica. A comparison of treatments in patients with subacute and chronic symptoms. Riv It Ossigeno-Ozonoterapia 2006;5:33-36.

Leonardi M, Andreula C, Simonetti L. Percutaneous techniques for treating disc disease. Funct Neurology. 2003;18:242-244.

Leonardi M, Barbara C, Agati R, Simonetti L, Giatti S. Trattamento percutaneo dell'ernia discale lombare con iniezione intradiscale di miscela di ozono. Riv Neuroradiol. 2001;14(1 suppl):51-53.

Leonardi M, Simonetti L, Agati R, Messia M, De-Santis F, Dani G. Recent CT advances in spine imaging. Riv Neuroradiol. 2001;14(1 suppl):207-212.

Leonardi M, Simonetti L, Agati R Neuroradiology of spine degenerative disease. Best Pract Res Clin Rheumatol. 2002;16:59-88.

Leonardi M, Simonetti L, Barbara C. The effects of the ozone on the nucleus pulposus: pathological data on one surgical specimen. Riv Neuroradiol. 2001;14:57-61.

Leonardi M, Simonetti L, Raffi L, Cenni P, Barbara C. Mini-invasive treatment of herniated disc by oxygen-ozone injection. Interv Neuroradiol. 2003;9(2 suppl):75.

Leonardi M, Simonetti L, Barbara C. Effetti dell'ozono sul nucleo polposo: reperti anatomo-patologici su un caso operato. Riv Neuroradiol. 2001;14(1 suppl):57-59.

Magalhaes FN, Dotta L, Sasse A, Teixera MJ, Fonoff ET. Ozone therapy as a treatment for low back pain secondary to herniated disc: a systematic review and meta-analysis of randomized controlled trials. Pain Physician. 2012 Mar-Apr;15(2)):E115-E129.

Muto M, Andreula C, Leonardi M. Treatment of herniated lumbar disc by intradiscal and intraforaminal oxygen-ozone (O2-O3) injection. J Neuroradiol 2004;31:183-189.

Pellicano F, Martinetti F, Tavanti V, Bonetti M, Leonardi M, Muto M, Andreula C, Villari N. The Italian Oxygen-Ozone Therapy Federation (FIO) study on oxygen-ozone treatment of herniated disc. Int J Ozone Therap. 2007;6:7-15.

Steppan J, Meaders T, Muto M, Murphy KJ. A metaanalysis of the effectiveness and safety of ozone treatments for herniated lumbar discs. J Vasc Interv Radiol. 2010 Apr;21(4):534-48.

Perri M, Grattacaso G, Di Tunno V, Marsecano C, Di Cesare E, Splendiani A, Gallucci M. MRI DWI/ADC signal predicts shrinkage of lumbar disc herniation after O2-O3 discolysis. Neuroradiol J. 2015;28(2):198-204.

Rahimi-Movaghar V, Eslami V. The major efficient mechanisms of ozone therapy are obtained in intradiscal procedures. Pain Physician. 2012 Nov-Dec;15(6):E1007-E1008.

Splendiani A, Perri M, Conchiglia A, Fasano F, Di Egidio G, Masciocchi C, Gallucci M. (2013) MR assessment of lumbar disk herniation treated with oxygen-ozone diskolysis: the role of DWI and related ADC versus intervertebral disk volumetric analysis for detecting treatment response. Neuroradiol J. 2013;26(3):347-56.

Sizer PS Jr, Phelps V, Matthijs O. (2001) Pain generators of the lumbar spine. Pain Pract. 2001;1(3):255-73.

Czervionke LF, Fenton DS. Fat-saturated MR imaging in the detection of inflammatory facet arthropathy (facet synovitis) in the lumbar spine. Pain Med. 2008;9(4):400-406.

Freira S, Fonseca H, Ferreira PD, Vasconcelos P, Fonseca JE. SAPHO syndrome in an adolescent: a clinical case with unusual severe systemic impact. J Adolesc Health. 2014;55(2):304-306.

Parlier-Cuau C, Laredo J. Vertebral involvement in SAPHO syndrome. J Radiol. 2010;91(9 Pt 2):1068-1078. doi:10.1016/s0221-0363(10)70151-7.

D'Aprile P, Tarantino A, Lorusso V, Brindicci D. Fat saturation technique and gadolinium in MRI of lumbar spinal degenerative disease. Neuroradiol J. 2006;30;19(5):654-671. doi:10.1177/197140090601900518.

D'Aprile P, Tarantino A, Jinkins JR, Brindicci D. The value of fat saturation sequences and contrast medium administration in MRI of degenerative disease of the posterior/perispinal elements of the lumbosacral spine. Eur Radiol. 2007;17(2):523-531. doi: 10.1007/s00330-006-0324-0.

Journal of Ozone Therapy, Volume 4, Number 5, 2020

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Published

2020-12-18

How to Cite

Bonetti, M., Zambello, A., Leonardi, M., & Princiotta, C. (2020). “Not just herniated disc” back pain: Outcome of oxygen-ozone treatment in selected applications. Journal of Ozone Therapy, 4(5), 1–12. https://doi.org/10.7203/jo3t.4.5.2020.10811
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Vol. 4 No. 5 (2020)

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