The role and the effects of the ozone paravertebral injections, in lumbar disc herniation patients.

Gabriel Calle; Lucio Huayhua; Alexis Martinez

doi:10.7203/jo3t.4.5.2020.18023

Autors/ores

Gabriel Calle Staff Espinal Argentina
Lucio Huayhua Staff Espinal Argentina
Alexis Martinez Staff Espinal Argentina

DOI:

https://doi.org/10.7203/jo3t.4.5.2020.18023

Paraules clau:

discal herniation, ozone therapy, ozone paravertebral intramuscular injections, minimal invasive spinal approach, low Back pain

Resum

The results obtained from a group of patients suffering from discoradicular conflict syndrome treated with paravertebral oxygen-ozone injections were analyzed. From a total number of 8500 patients treated with ozone during the period 2002/2015, 880 patients underwent intradiscal injection and 7620 patients were treated with paravertebral ozone injections. This paper analyses a subgroup of 1850 patients (24.28% of the patients who were treated with paravertebral injections), including those patients who underwent the total 10-session treatment, complied with a 5-year follow-up and with the sample homogeneity parameters following a predictability therapeutic effectiveness (PET) index devised for such purpose (PET index O3) by us in 2009. The outcomes were assessed based on the VAS score and modified Mac Nab criteria. Definite results determined positive post-treatment outcomes considered excellent and good in 81% of the cases. Such effectiveness percentage resulted lower than the one achieved with the intradiscal injection technique (89%), and higher than the percentage seen in papers on the selective nerve root block technique.

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Referències

Bocci V. Ossiigeno-ozonoterapia. Comprensione dei meccanismi di azione e possibilita terapeutiche. Rozzano (Milan): CEA Casa Editrice Ambrosiana; 2000. 352 p. ISBN: 8808084175.

Corea F, Amici S, Murgia N. A case of vertebrobasilar stroke during oxygen-ozone therapy. J Stroke Cerebrovasc Dis. 2004;13(6):259-261.

Marchetti O, LaMonaca G. An unexpected death during oxygen-ozone therapy. Am J Forensic Med Pathol. 2000;21(2):144-147.

Verga C. Nuovo approccio terapeutico alle ernie protusioni discali lombari. Riv Neuroradiol. 1989;2:1489.

Pietrogrande V. The therapy involving the infiltration of oxygen-ozone intradisc and interfacet. Paper presented at: I Congreso de la Sociedad Española de Abordajes Percutaneos Vertebrales; 1995 June 29-30; Barcelona, Spain.

Alexandre A, Fumo G. Discolisi percutánea mediante O2O3 nell´hernia discale lombare. In: Ceccherelli F, Ricciardi A, eds. Lombailgie e lombociatalgie. Criteri di diagnosi e cura. Torino: Edizioni Libreria Cortina; 1998. p. 367-377.

Buric J, Alexandre A, Coro L, Azuelos A. Intradiscal ozone treatment of non-contained disc herniations. 18 months follow-up. Riv It Ossigeno-Ozonoterapia. 2003;2:153-160.

Paradiso R, Alexandre A. The different outcomes of patients with disc herniation either by microdisectomy or by intradiscal ozone injection. Acta Neurochir Suppl. 2005;92:139-142. DOI:10.1007/3-211-27458-8_30.

Palmgren T, Gronbland M, Virri J, Kaapa E, Karaharju E. An inmunohistochemical study of nerve structures in anulus fibrosus of human normal lumbar intervertebral disc. Spine. 1999;24:2075-2079.

MacNab I. Negative disc exploration: an analysis of the cause of nerve root involvement in sixty-eight patients. J Bone Joint Surg (Am). 1971;53:891-903.

Paoloni M, DiSante L, Caccio A, Apuzzo D, Marotta S, Razzano M, Franzini M, Santilli V. Intramuscular oxygen-ozone therapy in the treatment of acute back pain with lumbar disc herniation: A multicenter, randomized, double-blind, clinical trial of active and simulated lumbar paravertebral injection. Spine. 2009;34:1337-1344.

Mirabelli F, Salis A, Bellomo G, et al. Surface blebbing and cytoskeletal abnormalities caused by sulphydril reagents in isolated hepatocytes, II: oxidizing reagents. Med Biol Environ. 1988;16:201-211.

Stephen J, Thomas-Meaders BS, Muto M, Murphy KJ. A metaanalysis of the effectiveness and safety of ozone treatments for herniated lumbar discs. J Vasc Interv Radiol. 2010;21(4):534-548. DOI:10.1016/j.jvir.2009.12.393.

Richellmi P, Valdenassi L, Berte F. Basi farmacologiche dell´azione dell´ ossigeno-ozono terapia. Riv Neuroradiol. 2001;14(1 suppl):17-22.

Andreula CF, Simonetti L, deSantis F, Agati R, Ricci R, Leonardi M. Minimally invasive oxygen-ozone therapy for lumbar disk herniation. Am J Neuroradiol. 2003;24(5):996-1000.

Simonetti L, Agati R, Cenni P, deSantis F, Leonardi M. Mechanism of pain in disc disease . Riv Neuroradiol. 2001;14(1 suppl):171-174.

Bocci V, Luzzi E, Corradeschi F, et al. Studies on the biological effects of ozone:III, an attempt to define conditions for optimal induction of cytokines.

Lymphokine Cytokine Res. 1993;12:121-126.

Iliakis E, Valadakis V, Tisiganos CP, Agapitos E. Rationalization of the activity of medical ozone on intervertebral disc: an histological and biochemical study. Rev Neuroradiol. 2001;14:23-30.

Leonardi M, Simonetti L, Barbara C. Effetti dell'ozono sul nucleo polposo: reperti anatomo-patologici su un caso operato. Riv Neuroradiol. 2001;14(1 suppl):57-59.