The RNA World: Piecing together the historical development of a hypothesis

Authors

  • Antonio Lazcano UNAM, Mexico City (Mexico).

DOI:

https://doi.org/10.7203/metode.6.5146

Keywords:

Origin of life, RNA World, ribonucleotidyl coenzymes, catalytic RNA

Abstract

The concept of an RNA world is a hypothesis firmly rooted in empirical data and is part of a long and complex scientific perspective that goes back more than fifty years to the discovery of the central role RNA and ribonucleotides play in protein synthesis and biochemical reactions took place. As the understanding of RNA biology progressed, several independent proposals of protein-free primordial life forms were suggested. Although this possibility was strongly reinforced with the discovery of ribozymes, there are many definitions of the RNA world, including several contradictory ones. One could say that it was an early, perhaps primordial, stage during which RNA molecules played a much more conspicuous role in heredity and metabolism and, particularly, in the origin and early evolution of protein biosynthesis. The overwhelming evidence for the catalytic, regulatory, and structural properties of RNA molecules, combined with their ubiquity in cellular processes, can only be explained with the proposal that they played a key role in early evolution and perhaps in the origin of life itself.

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Author Biography

Antonio Lazcano, UNAM, Mexico City (Mexico).

Full Professor of the origin of life at the National Autonomous University of Mexico. He is the author of scientific papers and books on the early stages of the evolution of life and has a long career in science communication in written media, radio, and television. He is the director of the Lynn Margulis Galapagos Centre. He was the President of the ISSOL twice and was made an Honorary Doctor by the universities of Milan, Valencia, and Michoacán. Since 2014, he has been a member of El Colegio Nacional, the highest cultural and scientific distinction in Mexico. His current research interests include the chemistry of the origin of life and the use of phylogenomic databases to reconstruct the early stages of cell evolution.  

References

Bada, J. L., & Lazcano, A. (2003). Prebiotic soup: Revisiting the Miller experiment. Science, 300, 745–746. doi: 10.1126/science.1085145

Belozerskii A. N. (1959). On species specificity of nucleic acids in bacteria. In A. I. Oparin, A. G. Pasynskii, A. E. Braunshetin, & T. E. Pavloskaya (Eds.), The origin of life on Earth (pp. 322–331). New York: Pergamon Press/MacMillan Company.

Brachet, J. (1959). Les acides nucléiques et l’origine des proteins. In A. I. Oparin, A. G. Pasynskii, A. E. Braunshetin, & T. E. Pavloskaya (Eds.), The origin of life on Earth (pp. 361–367). New York: Pergamon Press/MacMillan Company.

Crick F. H. C. (1968). The origin of the genetic code. Journal of Molecular Biology, 39, 367–379.

Eakin, R. E. (1963). An approach to the evolution of metabolism. Proceedings of the National Academy of Sciences, 49, 360–366. Gilbert, W. (1986). The RNA World. Nature, 319, 618. doi: 10.1038/319618a0

Handler, P. (1963). Evolution of the coenzymes. In A. I. Oparin (Ed.), Proceedings of the Fifth International Congress of Biochemistry, Vol. III. Biochemistry (pp. 149–157). New York: Pergamon Press/Macmillan Company.

Lazcano, A. (2012). The biochemical roots of the RNA world: From zymonucleic acid to ribozymes. History and Philosophy of the Life Sciences, 34, 407–424.

Maurel, M. C., & Ninio, J. (1987). Catalysis by a prebiotic nucleotide analog of histidine. Biochimie, 69, 551–553.

Oparin, A. I. (1938). The origin of life. New York: MacMillan.

Oparin, A. I., Pasynskii, A. G., Braunshetin, A. E., & Pavloskaya, T. E. (Eds.). (1959). The origin of life on Earth. New York: Pergamon Press/MacMillan Company.

Orgel, L. E. (1968). Evolution of the genetic apparatus. Journal of Molecular Biology, 38, 381–393.

Orgel, L. E., & Sulston, J.E. (1971). Polynucleotide replication and the origin of life. In A. P. Kimball, & J. Oró (Eds.), Prebiotic and biochemical evolution (pp. 89–94). Amsterdam: North-Holland.

Rich, A. (1962). On the problems of evolution and biochemical information transfer. In M. Kasha, & B. Pullman (Eds.), Horizons in biochemistry (pp. 103–126). New York: Academic Press.

White III, H. B. (1976). Coenzymes as fossils of an earlier metabolic state. Journal of Molecular Evolution, 7, 101–104.

Woese, C. R. (1967). The Genetic Code: The molecular basis for gene expression. New York: Harper and Row.

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Published

2016-04-15

How to Cite

Lazcano, A. (2016). The RNA World: Piecing together the historical development of a hypothesis. Metode Science Studies Journal, (6), 167–173. https://doi.org/10.7203/metode.6.5146
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Issue

Science grid: The public understanding of science (2016)

Section

On the origin of life. An incomplete scientific story

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